REDUCTION OF IRRITATION BY A NON-CORTICOSTEROID TOPICAL AGENT
Nancy Ann Monteiro-Riviere, Ph.D., Dipl. ABFM
Professor of Investigative Dermatology
Center for Cutaneous Toxicology and Residue Pharmacology
North Carolina State University
Raleigh, North Carolina
- Assess efficacy of Protèque Skin Protection System to modulate sodium lauryl sulfate (SLS) induced contact dermatitis
- Protèque Skin Protection System is a non-corticosteroid lotion consisting of dimethicone, triclosan (Irgasan DP300), tocopheryl acetate, Aloe Vera Gel, and Lonicera Japonica in a proprietary base formulation.
- White weanling Yorkshire pigs (n=4 replicates per treatment)
- SLS (1% and 3%) applied to 4.0 cm2 Hill Top Chambers provided a suitable degree of irritation assessed by a Draize erythema score (scale 0-4) at 24 and 48 hours.
- Effects of pre-treatment (15 minutes) and post-treatment with Protèque lotion was investigated to determine its effects on SLS-induced irritation.
- Effects of cleansing skin before Protèque lotion application was assessed.
- Role of triclosan was investigated using Protèque lotion with/without this additive.
- Effects of application of Protèque on reducing UVB-induced photo-irritation was also assessed in a separate study.
- SLS reproducibly induced a Draize level 2-3 erythema.
- Application of Protèque lotion significantly blocked erythema, especially when applied after SLS dosing
- These results were consistent whether 1 or 3% SLS was applied.
- Use of cleanser before Protèque lotion had no effect.
- Protèque lotion without triclosan was equally effective at reducing SLS-induced irritation
- UVB alone produced a Draize level 3 erythema, which pre-treatment with Protèque lotion reduced to a level 1.
- Protèque lotion reduced UVB-induced sunburn cell formation from 50 to 3, and reduced histological index of skin damage significantly.
- Application of Protèque lotion significantly reduced SLS-induced irritation when applied after SLS treatment. Triclosan was not the active ingredient modulating this effect.
- Similarly, treatment with Protèque lotion prior to UVB exposure markedly reduced the severity of sunburn achieved.
- These data confirm the efficacy of Protèque lotion to reduce SLS- and UVB-induced skin irritation.
We acknowledge the financial support from Protèque International, Inc. to conduct these studies.
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