REDUCTION OF IRRITATION BY A NON-CORTICOSTEROID TOPICAL AGENT

REDUCTION OF IRRITATION BY A NON-CORTICOSTEROID TOPICAL AGENT

Nancy Ann Monteiro-Riviere, Ph.D., Dipl. ABFM
Professor of Investigative Dermatology
Center for Cutaneous Toxicology and Residue Pharmacology
North Carolina State University
Raleigh, North Carolina

PURPOSE:

Assess efficacy of Protèque Skin Protection System to modulate sodium lauryl sulfate (SLS) induced contact dermatitis
Protèque Skin Protection System is a non-corticosteroid lotion consisting of dimethicone, triclosan (Irgasan DP300), tocopheryl acetate, Aloe Vera Gel, and Lonicera Japonica in a proprietary base formulation.

METHODS

White weanling Yorkshire pigs (n=4 replicates per treatment)
SLS (1% and 3%) applied to 4.0 cm²Hill Top Chambers provided a suitable degree of irritation assessed by a Draize erythema score (scale 0-4) at 24 and 48 hours.
Effects of pre-treatment (15 minutes) and post-treatment with Protèque lotion was investigated to determine its effects on SLS-induced irritation.
Effects of cleansing skin before Protèque lotion application was assessed.
Role of triclosan was investigated using Protèque lotion with/without this additive.
Effects of application of Protèque on reducing UVB-induced photo-irritation was also assessed in a separate study.

RESULTS

SLS reproducibly induced a Draize level 2-3 erythema.
Application of Protèque lotion significantly blocked erythema, especially when applied after SLS dosing
These results were consistent whether 1 or 3% SLS was applied.
Use of cleanser before Protèque lotion had no effect.
Protèque lotion without triclosan was equally effective at reducing SLS-induced irritation
UVB alone produced a Draize level 3 erythema, which pre-treatment with Protèque lotion reduced to a level 1.
Protèque lotion reduced UVB-induced sunburn cell formation from 50 to 3, and reduced histological index of skin damage significantly.

DISCUSSION

Application of Protèque lotion significantly reduced SLS-induced irritation when applied after SLS treatment. Triclosan was not the active ingredient modulating this effect.
Similarly, treatment with Protèque lotion prior to UVB exposure markedly reduced the severity of sunburn achieved.
These data confirm the efficacy of Protèque lotion to reduce SLS- and UVB-induced skin irritation.

We acknowledge the financial support from Protèque International, Inc. to conduct these studies.

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